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Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors - Nature Cell Biology

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Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors - Nature Cell Biology

Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of development (E)12.5 and E14.5, the number of transplantable HSCs in the murine FL expands from 50 to about 1,000. Here we used a non-invasive, multi-colour lineage tracing strategy to interrogate the embryonic expansion of murine haematopoietic progenitors destined to contribute to the adult HSC pool.

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Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors - Nature Cell Biology

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Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors - Nature Cell Biology

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