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MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution - Nature Structural & Molecular Biology

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MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution - Nature Structural & Molecular Biology

The linear sequence of DNA provides invaluable information about genes and their regulatory elements along chromosomes. However, to fully understand gene function and regulation, we need to dissect how genes physically fold in the three-dimensional nuclear space. Here we describe immuno-OligoSTORM, an imaging strategy that reveals the distribution of nucleosomes within specific genes in super-resolution, through the simultaneous visualization of DNA and histones.

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MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution - Nature Structural & Molecular Biology

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MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution - Nature Structural & Molecular Biology

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