The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals - The Pharmacogenomics Journal

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The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals - The Pharmacogenomics Journal

Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C83 and CYP2C92 alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses.

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The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals - The Pharmacogenomics Journal

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The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals - The Pharmacogenomics Journal

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The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals - The Pharmacogenomics Journal

Unlocking the Power of Knowledge
for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress