Article
Butyrate induces development-dependent necrotizing enterocolitis-like intestinal epithelial injury via necroptosis - Pediatric Research
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The accumulation of short-chain fatty acids (SCFAs) from bacterial fermentation may adversely affect the under-developed gut as observed in premature newborns at risk for necrotizing enterocolitis (NEC). This study explores the mechanism by which specific SCFA fermentation products may injure the premature newborn intestine mucosa leading to NEC-like intestinal cell injury.
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