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Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets - Nature Reviews Urology

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Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets - Nature Reviews Urology

Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma (ccRCC) but the underlying mechanisms and importance of this biological behaviour have remained enigmatic. De novo fatty acid (FA) synthesis, uptake and suppression of FA oxidation have all been shown to contribute to lipid storage, which is a necessary tumour adaptation rather than a bystander effect.

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Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets - Nature Reviews Urology

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Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets - Nature Reviews Urology

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