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Structural basis of colibactin activation by the ClbP peptidase - Nature Chemical Biology

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Structural basis of colibactin activation by the ClbP peptidase - Nature Chemical Biology

Colibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a non-toxic precursor assembled in the cytoplasm is activated after export to the periplasm. This activation is mediated by ClbP, an inner-membrane peptidase with an N-terminal periplasmic catalytic domain and a C-terminal three-helix transmembrane domain.

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Structural basis of colibactin activation by the ClbP peptidase - Nature Chemical Biology

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Structural basis of colibactin activation by the ClbP peptidase - Nature Chemical Biology

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