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Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism - Nature Metabolism

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Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism - Nature Metabolism

Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A Ganoderma meroterpene derivative (GMD) has been shown to alleviate obesity and hyperlipidemia through modulating the gut microbiota in obese mice. Here we show that GMD protects against obesity-associated atherosclerosis by increasing the abundance of Parabacteroides merdae in the gut and enhancing branched-chain amino acid (BCAA) catabolism.

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Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism - Nature Metabolism

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Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism - Nature Metabolism

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