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Small-molecule inhibition of the archetypal UbiB protein COQ8 - Nature Chemical Biology

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Small-molecule inhibition of the archetypal UbiB protein COQ8 - Nature Chemical Biology

Small-molecule tools have enabled mechanistic investigations and therapeutic targeting of the protein kinase-like (PKL) superfamily. However, such tools are still lacking for many PKL members, including the highly conserved and disease-related UbiB family. Here, we sought to develop and characterize an inhibitor for the archetypal UbiB member COQ8, whose function is essential for coenzyme Q (CoQ) biosynthesis.

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Small-molecule inhibition of the archetypal UbiB protein COQ8 - Nature Chemical Biology

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Small-molecule inhibition of the archetypal UbiB protein COQ8 - Nature Chemical Biology

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