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Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations - Nature Metabolism

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Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations - Nature Metabolism

Iron is essential to many fundamental biological processes, but its cellular compartmentalization and concentration must be tightly controlled. Although iron overload can contribute to obesity-associated metabolic deterioration, the subcellular localization and accumulation of iron in adipose tissue macrophages is largely unknown. Here, we show that macrophage mitochondrial iron levels control systemic metabolism in male mice by altering adipocyte iron concentrations.

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Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations - Nature Metabolism

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Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations - Nature Metabolism

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