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Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity - Nature Biotechnology

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Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity - Nature Biotechnology

Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base editors (ABEs). To develop a CBE that retains the small size, low off-target activity and high on-target activity of current ABEs, we evolved the highly active deoxyadenosine deaminase TadA-8e to perform cytidine deamination using phage-assisted continuous evolution.

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Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity - Nature Biotechnology

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Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity - Nature Biotechnology

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