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Cardiac Ca2+ current is 'Rad'-ically altered by adrenergic activation - Nature Cardiovascular Research

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Cardiac Ca2+ current is 'Rad'-ically altered by adrenergic activation - Nature Cardiovascular Research

The rapid enhancement of cardiac Ca2+ current (ICa,L) is central to enhanced heart function during the sympathetic fight-or-flight response. A new study shows how the small GTPase Rad mediates tonic ICa,L inhibition that is relieved after PKA-dependent phosphorylation of Rad, which causes release of Rad from the Ca2+ channel and increased ICa,L.

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Cardiac Ca2+ current is 'Rad'-ically altered by adrenergic activation - Nature Cardiovascular Research

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Cardiac Ca2+ current is 'Rad'-ically altered by adrenergic activation - Nature Cardiovascular Research

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