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FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion - Cell Death Discovery

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FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion - Cell Death Discovery

Recurrent implantation failure (RIF) is a rather thorny problem in the clinical practice of assisted reproductive technology. Due to the complex aetiology of RIF, its pathogenesis is far from fully understood, and there is no effective treatment available. Here, We explored the regulatory mechanism of the four half-domains of LIM domain 1 (FHL1), which is significantly downregulated in the endometrium of RIF patients, in blastocyst-epithelial adhesion.

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FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion - Cell Death Discovery

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FHL1 mediates HOXA10 deacetylation via SIRT2 to enhance blastocyst-epithelial adhesion - Cell Death Discovery

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Unlocking the Power of Knowledge for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress