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Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation - npj Biofilms and Microbiomes

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Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation - npj Biofilms and Microbiomes

The Clostridioides difficile pathogen is responsible for nosocomial infections. Germination is an essential step for the establishment of C. difficile infection (CDI) because toxins that are secreted by vegetative cells are responsible for the symptoms of CDI. Germination can be stimulated by the combinatorial actions of certain amino acids and either conjugated or deconjugated cholic acid-derived bile salts.

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Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation - npj Biofilms and Microbiomes

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Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation - npj Biofilms and Microbiomes

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