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Does immune cell exhaustion lie at the heart of BCG-unresponsive disease? - Nature Reviews Urology

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Does immune cell exhaustion lie at the heart of BCG-unresponsive disease? - Nature Reviews Urology

Immune system activation is necessary for BCG-mediated tumour immunity in non-muscle-invasive bladder cancer. However, mounting evidence supports the notion that dysfunctional activation, in the form of immune exhaustion, might contribute to BCG failure. Thus, an exhaustion signature, arising in treated tumours, could act as a predictive marker for BCG therapy.

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Does immune cell exhaustion lie at the heart of BCG-unresponsive disease? - Nature Reviews Urology

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Does immune cell exhaustion lie at the heart of BCG-unresponsive disease? - Nature Reviews Urology

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