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Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development - Cell Death Discovery

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Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development - Cell Death Discovery

Chromosome stability relies on bipolar spindle assembly and faithful chromosome segregation during cell division. Kinesin-5 Eg5 is a plus-end-directed kinesin motor protein, which is essential for spindle pole separation and chromosome alignment in mitosis. Heterozygous Eg5 mutations cause autosomal-dominant microcephaly, primary lymphedema, and chorioretinal dysplasia syndrome in humans. However, the developmental roles and cellular mechanisms of Eg5 in organogenesis remain largely unknown.

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Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development - Cell Death Discovery

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Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development - Cell Death Discovery

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