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Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration - Nature

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Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration - Nature

Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration at all stages of life. The technical limitation of senescent-cell scarcity3 was overcome by combining single-cell transcriptomics and a senescent-cell enrichment sorting protocol.

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Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration - Nature

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Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration - Nature

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