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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss - Nature Metabolism

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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss - Nature Metabolism

Leptin acts on hypothalamic neurons expressing agouti-related protein (AgRP) or pro-opiomelanocortin (POMC) to suppress appetite and increase energy expenditure, but the intracellular mechanisms that modulate central leptin signalling are not fully understood.

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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss - Nature Metabolism

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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss - Nature Metabolism

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