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Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection - Nature Biotechnology

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Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection - Nature Biotechnology

Cells interpret mechanical stimuli from their environments and neighbors, but the ability to engineer customized mechanosensing capabilities has remained a synthetic and mechanobiology challenge. Here we introduce tension-tuned synthetic Notch (SynNotch) receptors to convert extracellular and intercellular forces into specifiable gene expression changes.

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Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection - Nature Biotechnology

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Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection - Nature Biotechnology

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