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Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7 - Nature Cell Biology

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Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7 - Nature Cell Biology

Coenzyme Q (or ubiquinone) is a redox-active lipid that serves as universal electron carrier in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid peroxidation and ferroptosis. Mechanisms allowing cellular coenzyme Q distribution after synthesis within mitochondria are not understood. Here we identify the cytosolic lipid transfer protein STARD7 as a critical factor of intracellular coenzyme Q transport and suppressor of ferroptosis.

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Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7 - Nature Cell Biology

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Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7 - Nature Cell Biology

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