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Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals - Communications Biology

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Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals - Communications Biology

Herein, we studied the impact of empty LNP (eLNP), component of mRNA-based vaccine, on anti-viral pathways and immune function of cells from young and aged individuals. eLNP induced maturation of monocyte derived dendritic cells (MDDCs). We further show that eLNP upregulated CD40 and induced cytokine production in multiple DC subsets and monocytes. This coincided with phosphorylation of TANK binding kinase 1 (pTBK1) and interferon response factor 7 (pIRF7).

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Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals - Communications Biology

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Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals - Communications Biology

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