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Single-cell mapping of combinatorial target antigens for CAR switches using logic gates - Nature Biotechnology

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Single-cell mapping of combinatorial target antigens for CAR switches using logic gates - Nature Biotechnology

Identification of optimal target antigens that distinguish cancer cells from normal surrounding tissue cells remains a key challenge in chimeric antigen receptor (CAR) cell therapy for tumors with intratumoral heterogeneity. In this study, we dissected tissue complexity to the level of individual cells through the construction of a single-cell expression atlas that integrates ~1.4 million tumor, tumor-infiltrating normal and reference normal cells from 412 tumors and 12 normal organs.

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Single-cell mapping of combinatorial target antigens for CAR switches using logic gates - Nature Biotechnology

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Single-cell mapping of combinatorial target antigens for CAR switches using logic gates - Nature Biotechnology

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