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A molecular switch modulates assembly and host factor binding of the HIV-1 capsid - Nature Structural & Molecular Biology

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A molecular switch modulates assembly and host factor binding of the HIV-1 capsid - Nature Structural & Molecular Biology

The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is controlled by a molecular switch. Here, we identify a Thr-Val-Gly-Gly motif that modulates CA hexamer/pentamer switching by folding into a 310 helix in the pentamer and random coil in the hexamer.

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A molecular switch modulates assembly and host factor binding of the HIV-1 capsid - Nature Structural & Molecular Biology

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A molecular switch modulates assembly and host factor binding of the HIV-1 capsid - Nature Structural & Molecular Biology

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