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A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth - Cell Death & Disease

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A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth - Cell Death & Disease

Exploring novel molecularly-targeted therapies for endometrial carcinoma is important. The current study explored the potential anti-endometrial carcinoma activity by a first-in-class POLRMT (RNA polymerase mitochondrial) inhibitor IMT1. In patient-derived primary human endometrial carcinoma cells and established lines, treatment with IMT1 potently inhibited cell viability, proliferation, cell-cycle progression and motility, while inducing robust caspase-apoptosis activation.

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A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth - Cell Death & Disease

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A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth - Cell Death & Disease

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