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T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control - Nature Immunology

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T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control - Nature Immunology

Antigen-specific CD8+ T cell accumulation in tumors is a prerequisite for effective immunotherapy, and yet the mechanisms of lymphocyte transit are not well defined. Here we show that tumor-associated lymphatic vessels control T cell exit from tumors via the chemokine CXCL12, and intratumoral antigen encounter tunes CXCR4 expression by effector CD8+ T cells.

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cell lymphatic vessels antigen tumor cell biology biology microbiology

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T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control - Nature Immunology

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T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control - Nature Immunology

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