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Lipid-accumulated reactive astrocytes promote disease progression in epilepsy - Nature Neuroscience

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Lipid-accumulated reactive astrocytes promote disease progression in epilepsy - Nature Neuroscience

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the formation of lipid-accumulated reactive astrocytes (LARAs), a new reactive astrocyte subtype characterized by elevated APOE expression.

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Lipid-accumulated reactive astrocytes promote disease progression in epilepsy - Nature Neuroscience

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Lipid-accumulated reactive astrocytes promote disease progression in epilepsy - Nature Neuroscience

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