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Deep thermal profiling for detection of functional proteoform groups - Nature Chemical Biology

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Deep thermal profiling for detection of functional proteoform groups - Nature Chemical Biology

The complexity of the functional proteome extends considerably beyond the coding genome, resulting in millions of proteoforms. Investigation of proteoforms and their functional roles is important to understand cellular physiology and its deregulation in diseases but challenging to perform systematically. Here we applied thermal proteome profiling with deep peptide coverage to detect functional proteoform groups in acute lymphoblastic leukemia cell lines with different cytogenetic aberrations.

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Deep thermal profiling for detection of functional proteoform groups - Nature Chemical Biology

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Deep thermal profiling for detection of functional proteoform groups - Nature Chemical Biology

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