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Mechanism of receptor assembly via the pleiotropic adipokine Leptin - Nature Structural & Molecular Biology

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Mechanism of receptor assembly via the pleiotropic adipokine Leptin - Nature Structural & Molecular Biology

The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However, the structure and mechanism of Leptin-mediated LEP-R assemblies has remained unclear. Intriguingly, the signaling-competent isoform of LEP-R is only lowly abundant amid several inactive short LEP-R isoforms contributing to a mechanistic conundrum.

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Mechanism of receptor assembly via the pleiotropic adipokine Leptin - Nature Structural & Molecular Biology

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Mechanism of receptor assembly via the pleiotropic adipokine Leptin - Nature Structural & Molecular Biology

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