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Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment - Nature Communications

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Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment - Nature Communications

Cancer metastasis to the brain is a significant clinical problem. Metastasis is the consequence of favorable interactions between invaded cancer cells and the microenvironment. Here, we demonstrate that cancer-activated astrocytes create a sustained low-level activated type I interferon (IFN) microenvironment in brain metastatic lesions. We further confirm that the IFN response in astrocytes facilitates brain metastasis.

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Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment - Nature Communications

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Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment - Nature Communications

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