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MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange - Nature Chemical Biology
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Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II) proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large degree of allelic polymorphism influencing the peptide repertoire presented by the resulting MHC-II protein allotypes.
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