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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity - Nature Immunology

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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity - Nature Immunology

Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interferon-α/interferon-β (IFNα/β)-induced transcriptional adaptations that endow APCs with the capacity to rapidly activate the transcriptional regulators p65, IRF1 and FOS after CD4+ T cell-mediated CD40 stimulation.

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health coronavirus covid 19 immunity cells cd4 cell biology biology microbiology

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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity - Nature Immunology

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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity - Nature Immunology

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