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γ-Linolenic acid in maternal milk drives cardiac metabolic maturation - Nature

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γ-Linolenic acid in maternal milk drives cardiac metabolic maturation - Nature

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference from glucose to fatty acids for postnatal energy production1,2. This adaptation is triggered in part by post-partum environmental changes3, but the molecules orchestrating cardiomyocyte maturation remain unknown. Here we show that this transition is coordinated by maternally supplied γ-linolenic acid (GLA), an 18:3 omega-6 fatty acid enriched in the maternal milk.

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γ-Linolenic acid in maternal milk drives cardiac metabolic maturation - Nature

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γ-Linolenic acid in maternal milk drives cardiac metabolic maturation - Nature

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