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Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development - Nature Methods

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Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development - Nature Methods

The brain is a complex tissue whose function relies on coordinated anatomical and molecular features. However, the molecular annotation of the spatial organization of the brain is currently insufficient. Here, we describe microfluidic indexing-based spatial assay for transposase-accessible chromatin and RNA-sequencing (MISAR-seq), a method for spatially resolved joint profiling of chromatin accessibility and gene expression.

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Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development - Nature Methods

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Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development - Nature Methods

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