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11 months ago

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Histone modifications regulate pioneer transcription factor cooperativity - Nature

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Histone modifications regulate pioneer transcription factor cooperativity - Nature

Pioneer transcription factors have the ability to access DNA in compacted chromatin1. Multiple transcription factors can bind together to a regulatory element in a cooperative way, and cooperation between the pioneer transcription factors OCT4 (also known as POU5F1) and SOX2 is important for pluripotency and reprogramming2–4. However, the molecular mechanisms by which pioneer transcription factors function and cooperate on chromatin remain unclear.

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Histone modifications regulate pioneer transcription factor cooperativity - Nature

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Histone modifications regulate pioneer transcription factor cooperativity - Nature

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