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Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions - Nature Metabolism

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Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions - Nature Metabolism

Glucose is vital for life, serving as both a source of energy and carbon building block for growth. When glucose is limiting, alternative nutrients must be harnessed. To identify mechanisms by which cells can tolerate complete loss of glucose, we performed nutrient-sensitized genome-wide genetic screens and a PRISM growth assay across 482 cancer cell lines. We report that catabolism of uridine from the medium enables the growth of cells in the complete absence of glucose.

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Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions - Nature Metabolism

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Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions - Nature Metabolism

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