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Rational engineering of lung alveolar epithelium - npj Regenerative Medicine

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Rational engineering of lung alveolar epithelium - npj Regenerative Medicine

Engineered whole lungs may one day expand therapeutic options for patients with end-stage lung disease. However, the feasibility of ex vivo lung regeneration remains limited by the inability to recapitulate mature, functional alveolar epithelium. Here, we modulate multimodal components of the alveolar epithelial type 2 cell (AEC2) niche in decellularized lung scaffolds in order to guide AEC2 behavior for epithelial regeneration.

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Rational engineering of lung alveolar epithelium - npj Regenerative Medicine

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