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Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells - Cell Discovery

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Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells - Cell Discovery

Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve genomic stability. However, the molecular mechanisms underlying telomere attrition-induced genome instability remain to be understood. We systematically analyzed the expression of retrotransposons and performed genomic sequencing of different cell and tissue types with telomeres of varying lengths due to telomerase deficiency.

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Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells - Cell Discovery

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Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells - Cell Discovery

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