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mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission - Nature Cell Biology

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mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission - Nature Cell Biology

Fasting triggers diverse physiological adaptations including increases in circulating fatty acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving mitochondrial adaptations and respiratory sufficiency during fasting remain incompletely understood. Here we show that fasting or lipid availability stimulates mTORC2 activity.

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mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission - Nature Cell Biology

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mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission - Nature Cell Biology

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