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10 months ago

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A toolbox for studying the transcriptional diversity and functions of human microglia in vitro - Nature Immunology

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A toolbox for studying the transcriptional diversity and functions of human microglia in vitro - Nature Immunology

We have used human-derived stem cells to generate various microglial states and investigate the function of human microglia in a scalable manner. We were able to model disease-associated microglia that replicated transcriptional signatures found in human tissue, and further developed a lentiviral transfer system to manipulate human microglial states in vitro.

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A toolbox for studying the transcriptional diversity and functions of human microglia in vitro - Nature Immunology

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A toolbox for studying the transcriptional diversity and functions of human microglia in vitro - Nature Immunology

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