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9 months ago

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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing - Nature Communications

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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing - Nature Communications

Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended mutations represent major limitations for genome editing applications caused by the interplay with DNA double-strand break repair pathways.

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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing - Nature Communications

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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing - Nature Communications

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