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8 months ago

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Simultaneous profiling of chromatin architecture and transcription in single cells - Nature Structural & Molecular Biology

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Simultaneous profiling of chromatin architecture and transcription in single cells - Nature Structural & Molecular Biology

The three-dimensional structure of chromatin plays a crucial role in development and disease, both of which are associated with transcriptional changes. However, given the heterogeneity in single-cell chromatin architecture and transcription, the regulatory relationship between the three-dimensional chromatin structure and gene expression is difficult to explain based on bulk cell populations.

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Simultaneous profiling of chromatin architecture and transcription in single cells - Nature Structural & Molecular Biology

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Simultaneous profiling of chromatin architecture and transcription in single cells - Nature Structural & Molecular Biology

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