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Assembly of 43 human Y chromosomes reveals extensive complexity and variation - Nature

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Assembly of 43 human Y chromosomes reveals extensive complexity and variation - Nature

The prevalence of highly repetitive sequences within the human Y chromosome has prevented its complete assembly to date1 and led to its systematic omission from genomic analyses. Here we present de novo assemblies of 43 Y chromosomes spanning 182,900 years of human evolution and report considerable diversity in size and structure. Half of the male-specific euchromatic region is subject to large inversions with a greater than twofold higher recurrence rate compared with all other chromosomes2.

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Assembly of 43 human Y chromosomes reveals extensive complexity and variation - Nature

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Assembly of 43 human Y chromosomes reveals extensive complexity and variation - Nature

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