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Epitope editing enables targeted immunotherapy of acute myeloid leukaemia - Nature

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Epitope editing enables targeted immunotherapy of acute myeloid leukaemia - Nature

Despite the considerable efficacy observed when targeting a dispensable lineage antigen, such as CD19 in B cell acute lymphoblastic leukaemia1,2, the broader applicability of adoptive immunotherapies is hampered by the absence of tumour-restricted antigens3–5. Acute myeloid leukaemia immunotherapies target genes expressed by haematopoietic stem/progenitor cells (HSPCs) or differentiated myeloid cells, resulting in intolerable on-target/off-tumour toxicity.

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Epitope editing enables targeted immunotherapy of acute myeloid leukaemia - Nature

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Epitope editing enables targeted immunotherapy of acute myeloid leukaemia - Nature

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