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Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis - Communications Biology

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Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis - Communications Biology

Pyroptosis is a cell death process that causes inflammation and contributes to numerous diseases. Pyroptosis is mediated by caspase-1 family proteases that cleave the pore-forming protein gasdermin D, causing plasma membrane rupture and release of pathogenic cellular contents. We previously identified muscimol as a small molecule that prevents plasma membrane rupture during pyroptosis via an unidentified mechanism.

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Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis - Communications Biology

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Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis - Communications Biology

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