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Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold - Communications Biology

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Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold - Communications Biology

Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues.

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Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold - Communications Biology

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Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold - Communications Biology

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