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Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair - Nature Metabolism

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Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair - Nature Metabolism

Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B12 and molecular hallmarks of methionine starvation. Supplementation with vitamin B12 increases the efficiency of reprogramming both in mice and in cultured cells, the latter indicating a cell-intrinsic effect.

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Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair - Nature Metabolism

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Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair - Nature Metabolism

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