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ID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer - Nature Communications

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ID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer - Nature Communications

Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the prominant population of immune cells in tumor tissues, contributing to the formation of CSC niches and a suppressive immune microenvironment. Here, we report that high expression of inhibitor of differentiation 1 (ID1) in TAMs correlates with poor outcome in patients with colorectal cancer (CRC).

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ID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer - Nature Communications

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ID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer - Nature Communications

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