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AGO2 localizes to the nucleus in quiescence and represses transposon expression - Nature Structural & Molecular Biology

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AGO2 localizes to the nucleus in quiescence and represses transposon expression - Nature Structural & Molecular Biology

An Ago2HA/HA mouse model combined with super-resolution microscopy, molecular and biochemical assays allowed us to stringently characterize AGO2 regulation in vivo. We found that in quiescent splenocytes, AGO2 localizes almost exclusively to the nucleus, where it binds to the RNA of young mobile transposons and represses their expression through its catalytic domain.

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AGO2 localizes to the nucleus in quiescence and represses transposon expression - Nature Structural & Molecular Biology

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AGO2 localizes to the nucleus in quiescence and represses transposon expression - Nature Structural & Molecular Biology

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