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HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes - Nature

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HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes - Nature

Human immunodeficiency virus 1 (HIV-1) infection is initiated by binding of the viral envelope glycoprotein (Env) to the cell-surface receptor CD41–4. Although high-resolution structures of Env in a complex with the soluble domains of CD4 have been determined, the binding process is less understood in native membranes5–13. Here we used cryo-electron tomography to monitor Env–CD4 interactions at the membrane–membrane interfaces formed between HIV-1 and CD4-presenting virus-like particles.

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HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes - Nature

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HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes - Nature

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