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Pyruvate metabolism regulates prostate cell fate and response to cancer therapy - Nature Cell Biology

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Pyruvate metabolism regulates prostate cell fate and response to cancer therapy - Nature Cell Biology

Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered that inhibition of mitochondrial pyruvate uptake results in large-scale chromatin remodelling of key lineage-specific genes, antagonizes luminal lineage identity, and alters response to antiandrogen therapy in prostate cancer.

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Pyruvate metabolism regulates prostate cell fate and response to cancer therapy - Nature Cell Biology

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Pyruvate metabolism regulates prostate cell fate and response to cancer therapy - Nature Cell Biology

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