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Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers - Nature Chemistry

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Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers - Nature Chemistry

The appeal of catalytic click chemistry is largely due to the copper-catalysed azide–alkyne cycloaddition (CuAAC) process, which is orthogonal to the more recently introduced sulfur–fluoride exchange (SuFEx). However, the triazole rings generated by CuAAC are not readily modifiable, and SuFEx connectors cannot be selectively functionalized, attributes that would be attractive in a click process.

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Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers - Nature Chemistry

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Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers - Nature Chemistry

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